Publications

1

C.-K. Chiou, Y.-L. Liu, P.-J. Huang, P.-H. Tsou, C.-T Chen, H.-H. Lee, Y.-N. Wang, J.L. Hsu, J.-F. Lee, T.E. Yankeelov, J. Kameoka*, H.-C. Yeh*, and M.-C. Hung*, "Digital receptor occupancy assay in quantifying on- and off-target binding affinities of therapeutic antibodies", ACS Sensors 5, 296-302, 2020.

2

Y.-L. Liu*, E.P. Perillo, P. Ang, M. Kim, D.T. Nguyen, K. Blocher, Y.-A. Chen, C. Liu, A.M. Hassan, H.T. Vu, A.K. Dunn and H.-C. Yeh* ( co-corresponding authors), "Development of three-dimensional two-color dual-particle tracking microscope and its applications in monitoring DNA conformational changes and antibody-conjugated nanoparticle landings on the plasma membrane", ACS Nano, 2020.

3

M.S. Blevins, D. Kim, C.M. Crittenden, S. Hong, H.-C. Yeh, J.T. Petty and J.S. Brodbelt, "Footprints of nanoscale DNA-silver cluster chromophores via activated-electron photodetachment mass spectrometry", ACS Nano 13, 14070-14079, 2019.

4

X. Peng, X. Liu, Y.-L. Liu, J.Y. Kim, Y.-I. Chen, P. Ang, A. Nguyen, J. Leal, H.-C. Yeh and D. Ghosh, "Brain-penetrating peptide shuttles through the blood-brain barrier and extracellular-like space", ChemRxiv, 2019.

5

Y.-I. Chen, Y.-J. Chang, T.D. Nguyen, C. Liu, S. Phillion, Y.-A. Kuo, H.T. Vu, A. Liu, Y.-L. Liu, S. Hong, P. Ren, T.E. Yankeelov and H.-C. Yeh, "Measuring DNA hybridization kinetics in live cells using a time-resolved 3D single-molecule tracking method", Journal of the American Chemical Society 141(40): 15747-15750, 2019.

6

Y.-L. Liu, A.M. Horning, B. Lieberman, C.-K. Lin, C.-N. Hung, C.-W. Chou, C.-M. Wang, M.A. Liss, M. Kim, R. Vasisht, E.P. Perillo, K. Blocher, H. Horng, A.K. Dunn, T. H.-M. Huang, H.-C. Yeh and C.-L. Chen, "Spatial EGFR dynamics and metastatic phenotypes modulated by upregulated EPHB2 and SRC pathways predicting poor prognosis", Cancer 11, 1910, 2019.

7

Y.-L. Liu, C.-K. Chou; M. Kim, R. Vasisht, Y.-A. Kuo, C. Liu, E.P. Perillo, Y.-A. Chen, K. Blocher, H. Horng, Y.-I Chen, D.T. Nguyen, T. Yankeelov, M.-C. Hung, A. Dunn, and H.-C. Yeh, "Assessing metastatic potential of breast cancer cells based on EGFR dynamics", Scientific Reports 9, 3395, 2019.

8

A.M. Hassan, X. Wu, J.W. Jarrett, S. Xu, J. Yu, D.R. Miller, E.P. Perillo, Y.-L. Liu, D.T. Chiu, H.-C. Yeh*, and A.K. Dunn* (co-corresponding authors) "Polymer dots enable deep in vivo multiphoton fluorescence imaging of microvasculature," Biomedical Optics Express 10(2): 584-599, 2019.

9

H.T. Vu, S. Hong and H.-C. Yeh, "Fluorescence Biosensors," in Advances in Biosensing Technology for Medical Diagnosis, edited by H.-S. Chuang and Y.-P. Ho, Bentham Science, 2019.

10

Y.-A. Chen, H.T. Vu, Y.-L. Liu, Y.-I Chen, T.D. Nguyen, Y.-A. Kuo, S. Hong, Y.-A. Chen, S. Carnahan, J.T. Petty and H.-C. Yeh, "Improving NanoCluster Beacon performance by blocking the unlabeled NC probes," Chemical Communications 55, 462-465, 2019.

11

C.-K. Chou, P.-J. Huang, P.-H. Tsou, Y. Wei, H.-H. Lee, Y.-N. Wang, Y.-L. Liu, C. Shi, H.-C. Yeh, J. Kameoka, and M.-C. Hung, "A flow-proteometric platform for analyzing protein concentration (FAP): Proof of concept for quantification of PD-L1 protein in cells and tissues", Bioelectronics and Biosensors 117, 97-103, 2018.

12

V. Le, J. Lee, S. Chaterji, A. Spencer, Y.-L. Liu, P. Kim, H.-C. Yeh, D.-H. Kim and A.B. Baker, "Syndecan-1 in mechanosensing of nanotopological cues in engineered materials," Biomaterials 155, 13-24, 2018.

13

A.M. Hassan, X. Wu, J.W. Jarrett, S. Xu, D.R. Miller, J. Yu, E.P. Perillo, Y.-L. Liu, D.T. Chiu, H.-C. Yeh*, and A.K. Dunn* (co-corresponding authors) "Polymer dots enable deep in vivo multiphoton fluorescence imaging of cerebrovascular architecture," SPIE Proceedings , 104982Y, 2018.

14

C.-W. Li, S.-O. Lim, E.M. Chung, Y.-S. Kim, A.H. Park, J.-H. Cha, W. Xia, L.-C. Chan, T. Kim, S.-S. Chang, H.-H. Lee, C.-K. Chou, Y.-L. Liu, H.-C. Yeh, E.P. Perillo, A.K. Dunn, C.-W. Kuo, K.-H. Khoo, J.L. Hsu, Y. Wu, J.-M. Hsu, H. Yamaguchi, J. Yao, A.A. Sahin, G.N. Hortobagyi, S.S. Yoo and M.-C. Hung, "Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1," Cancer Cell 33(2): 187-201, 2018.

15

E.P. Perillo, J.W. Jarrett, Y.-L. Liu, A. Hassan, D.C. Fernée, J.R. Goldak, A. Bonteanu, D.J. Spence, H.-C. Yeh and A.K. Dunn, "Two-color multiphoton in vivo imaging with a femtosecond diamond Raman laser," Light: Sciences & Applications 6, e17095, 2017.

16

J.M. Obliosca, S.Y. Cheng, Y.-A. Chen, M.F. Llanos, Y.-L. Liu, D.M. Imphean, D. Bell, J.T. Petty, P. Ren and H.-C. Yeh, "LNA thymidine monomer enables differentiation of the four single-nucleotide variants by melting temperature," Journal of the American Chemical Society 139(20): 7110-7116, 2017.

17

C. Liu, A. Rastogi and H.-C. Yeh, "Quantification of rare single-molecule species based on fluorescence lifetime," Analytical Chemistry 89(9): 4772-4775, 2017.

18

C. Liu, J.M. Obliosca, Y.-L. Liu, Y.-A. Chen, N. Jiang and H.-C. Yeh, "3D single-molecule tracking enables direct hybridization kinetics measurement in solution," Nanoscale 9: 5664-5670, 2017.

19

Y.-L. Liu, E.P. Perillo, C. Liu, P. Yu, C.-K. Chou, M.-C. Hung, A.K. Dunn and H.-C. Yeh, "Segmentation of 3D trajectories acquired by TSUNAMI microscope: an application to EGFR trafficking," Biophysical Journal 111(10): 2214-2227, 2016.

20

C. Liu, Y.-L. Liu, E.P. Perillo, A.K. Dunn and H.-C. Yeh, "Single-molecule tracking and its application in biomolecular detection," IEEE Journal of Selected Topics in Quantum Electronics 22(4): 6804013, 2016.

21

E.P. Perillo, J.E. McCracken, D.C. Fernée, J.R. Goldak, F.A. Medina, D.R. Miller, H.-C. Yeh, and A.K. Dunn, "Deep in vivo two-photon microscopy with a low cost custom built mode-locked 1060 nm fiber laser," Biomedical Optics Express 7(2): 324-334, 2016.

22

C. Liu*, Y.-L. Liu* (equal contribution), E.P. Perillo, N. Jiang, A.K. Dunn and H.-C. Yeh, "Improving z-tracking accuracy in the two-photon single-particle tracking microscope," Applied Physics Letters 107, 153701, 2015.

23

Y.-A. Chen*, J.M. Obliosca* (equal contribution), Y.-L. Liu, C. Liu, M.L. Gwozdz, and H.-C. Yeh, "NanoCluster Beacons enable detection of a single N6-methyladenine," Journal of the American Chemical Society 137(33): 10476-10479, 2015.

24

E. P. Perillo, Y.-L. Liu, K. Huynh, C. Liu, C.-K. Chou, M.-C. Hung, H.-C. Yeh*, and A. Dunn* (co-corresponding authors) "Deep and high-resolution three-dimensional tracking of single particles using nonlinear and multiplexed illumination," Nature Communications 6, 7874, 2015.

25

S. Juul*, J.M. Obliosca* (equal contribution), C. Liu, Y.-L. Liu, Y.-A. Chen, D.M. Imphean, B. R. Knudsen, Y.-P. Ho, K.W. Leong, and H.-C. Yeh, "NanoCluster Beacons as reporter probes in rolling circle enhanced enzyme activity detection," Nanoscale 7, 8332-8337, 2015.

26

E. Perillo, Y.-L. Liu, C. Liu, H.-C. Yeh, and A.K. Dunn, "Single particle tracking through highly scattering media with multiplexed two-photon excitation," SPIE Proceedings 933107, 2015.

27

J.M. Obliosca, M.C. Babin, C. Liu, Y.-L. Liu, Y.-A. Chen, R.A. Batson, M. Ganguly, J.T. Petty, and H.-C. Yeh, "A complementary palette of NanoCluster Beacons," ACS Nano 8(10): 10150-10160, 2014.

28

C. Liu, E.P. Perillo, Q. Zhuang, K.T. Huynh, A.K. Dunn, and H.-C. Yeh, "3D single-molecule tracking using one- and two-photon excitation microscopy," SPIE Proceedings 89501C, 2014.

29

E.P. Perillo, L. De Haro, M.E. Phipps, J.S. Martinez, H.-C. Yeh, A.K. Dunn, D.P. Shepherd, and J.H. Werner, "Enhanced 3D localization of individual RNA transcripts via astigmatic imaging," SPIE Proceedings 895003, 2014.

30

J.M. Obliosca, C. Liu, and H.-C. Yeh, "Fluorescent silver nanoclusters as DNA probes," Nanoscale 5: 8443-8461, 2013.

31

J.M. Obliosca, C. Liu, R.A. Batson, M.C. Babin, J.H. Werner, and H.-C. Yeh, "DNA/RNA detection using DNA-templated few-atom silver nanoclusters," Biosensors 3(2): 185-200, 2013.

32

H.-C. Yeh, J. Sharma, I.-M. Shih, D.M. Vu, J.S. Martinez, and J.H. Werner, "A fluorescence light-up Ag nanocluster probe that discriminates single-nucleotide variants by emission color," Journal of the American Chemical Society 134(28): 11550-11558, 2012.

33

S.H. Yau, N. Abeyasinghe, M. Orr, L. Upton, O. Varnavski, J.H. Werner, H.-C. Yeh, J. Sharma, A.P. Shreve, J.S. Martinez, and T. Goodson III, "Bright two-photon emission and ultra-fast relaxation dynamics in a DNA-templated nanocluster investigated by ultra-fast spectroscopy," Nanoscale 4: 4247-4254, 2012.

34

J. Sharma, R.C. Rocha, M.L. Phipps, H.-C. Yeh, K.A. Balatsky, D.M. Vu, A.P. Shreve, J.H. Werner, and J.S. Martinez, "A DNA-templated fluorescent silver nanocluster with enhanced stability," Nanoscale 4: 4107-4110, 2012.

35

M.L. Neidig, J. Sharma, H.-C. Yeh, J.S. Martinez, S.D. Conradson, and A.P. Shreve, "Ag K-edge EXAFS of DNA-templated fluorescent silver nanoclusters: insight into the structural origins of emission tuning by DNA sequence variation," Journal of the American Chemical Society 133(31): 11837-11839, 2011.

36

J. Sharma, H.-C. Yeh, H. Yoo, J.H. Werner, and J.S. Martinez, "Silver nanocluster aptamers: in situ generation of intrinsically fluorescent recognition ligands for protein detection," Chemical Communications 47(8): 2294-2296, 2011.

37

H.-C. Yeh, J. Sharma, J.J. Han, J.S. Martinez, and J.H. Werner, "A beacon of light: a new molecular probe for homogeneous detection of nucleic acid targets," IEEE Nanotechnology Magazine 5(2): 28-33, 2011.

38

H.-C. Yeh, J. Sharma, J.J. Han, J.S. Martinez, and J.H. Werner, "A DNA-silver nanocluster probe that fluoresces upon hybridization," Nano Letters 10(8): 3106-3110, 2010.

39

J. Sharma*, H.-C. Yeh* (*equal contribution), H. Yoo, J.H. Werner, and J.S. Martinez, "A complementary palette of fluorescent silver nanoclusters," Chemical Communications 46(19): 3280-3282, 2010.

40

H. Yoo, J. Sharma, H.-C. Yeh, and J.S. Martinez, "Solution-phase synthesis of Au fibers using rod-shaped micelles as shape directing agents," Chemical Communications 46(36): 6813-6815, 2010.

41

Y. Bao, H.-C. Yeh, C. Zhong, S.A. Ivanov, J. Sharma, M.L. Neidig, D.M. Vu, A.P. Shreve, R.B. Dyer, J.H. Werner, and J.S. Martinez, "Formation and stabilization of fluorescent gold nanoclusters using small molecules," Journal of Physical Chemistry C 114(38): 1587915882, 2010.

42

H.-C. Yeh, J. Sharma, H. Yoo, J.S. Martinez, and J.H. Werner, "Photophysical characterization of fluorescent metal nanoclusters synthesized using oligonucleotides, proteins and small molecule ligands," SPIE Proceedings 7576, 75760N, 2010.

43

H.-C. Yeh, C. Puleo, Y.-P. Ho, V. Bailey, T.C. Lim, K. Liu, and T.-H. Wang, "Tunable blinking kinetics of Cy5 for precise DNA quantification and single-nucleotide difference detection," Biophysical Journal 95(2): 729-737, 2008.

45

Y. Joo, H.-C. Yeh, K. Dieu, and C.-J Kim, "Air cooling of a microelectronic chip with diverging metal microchannels monolithically processed using a single mask," Journal of Micromechanics and Microengineering 18(11): 115022, 2008.

46

C. Puleo, H.-C. Yeh, and T.-H. Wang, "Applications of MEMS technologies in tissue engineering," Tissue Engineering 13(12): 2839-2854, 2007.

47

H.-C. Yeh, C. Puleo, T.C. Lim, Y.-P. Ho, P. Giza, R.-C. Huang, and T.-H. Wang. "A microfluidic-FCS platform for investigation on the dissociation of Sp1-DNA complex by doxorubicin," Nucleic Acids Research 34(21): e144, 2006.

48

H.-C. Yeh, Y.-P. Ho, I.-M. Shih, and T.-H. Wang, "Homogeneous point mutation detection by quantum dot-mediated two-color fluorescence coincidence analysis," Nucleic Acids Research 34(5): e35, 2006.

49

C. Zhang, H.-C. Yeh, M. Kuroki, and T.-H. Wang, "Single-quantum-dot-based DNA nanosensor," Nature Materials 4(11): 826-831, 2005.

50

H.-C. Yeh, S.-Y. Chao, Y.-P. Ho, and T.-H. Wang, "Single-molecule detection and probe strategies for rapid and ultrasensitive genomic detection," Current Pharmaceutical Biotechnology 6(6): 453-461, 2005.

51

H.-C. Yeh, Y.-P. Ho, and T.-H. Wang, "Quantum dot–mediated biosensing assays for specific nucleic acid detection," Nanomedicine: Nanotechnology, Biology and Medicine 1(2): 115-121, 2005.